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Dose- and time-dependent effect of IL-27 on the induction of chemokine release from control and RA-FLS. Control and RA-FLS were cultured with IL-27 (50 ng/ml) for 48 h and induction of (A) CCL2, (C) CXCL9 and (E) CXCL10 was analysed by CBA using flow cytometry. (B, D, F) Control and RA-FLS were stimulated with IL-27 (0 to 100 ng/ml) for 12 to 48 h and inductions of (B) CCL2, (D) CXCL9 and (F) CXCL10 were analysed by CBA using flow cytometry. *P < 0.05, **P < 0.01, ***P < 0.001.
