Table 3.

Best-fit models for clinical score, and cartilage and bone destruction predicted by different serum markers

Dependent variable	Best-fit model	Adjusted R2	Significance
Clinical score	MMP-3	0.414	< 0.001
	MMP-3 + anti-collagen IgG2a	0.499	< 0.001
Cartilage destruction	MMP-3	0.451	< 0.001
	MMP-3 + CTXII	0.485	< 0.001
Bone destruction	MMP-3	0.372	< 0.001
	MMP-3 + anti-collagen IgG2a	0.411	< 0.001

Best-fit models for clinical score, and cartilage and bone destruction in the knee joint as proposed by linear regression analysis with nine serum markers and treatment group as independent variables. MMP-3, matrix metalloproteinase-3.