Table 1.

Summary of trials of erythropoietin in acutely critically ill patients

Year	Reference	n total	n sepsis	Enrolment	Dose	Duration
1995	Still and colleagues [96]	40	0	> 3 days	150 IU/kg three times/week	30 days
1998	Gabriel and colleagues [93]	21	ns	ICU admission	600 IU/kg three times/week	Maximum 3 weeks
1999	Corwin and colleagues [92]	80	6	Day 3	300 IU/kg daily for 5 days	Maximum 6 weeks
2000	van Iperen and colleagues [97]	36	23	Hb < 11.2 g/dl	300 IU/kg alternate days for 5 days	5 doses
2002	Corwin and colleagues [87]	1,352	105	Day 3	40,000 IU/week	Maximum 3 weeks
2005	Georgopoulos and colleagues [94]	148	ns	Hb < 12.0 g/dl	40,000 IU/week	Maximum 3 weeks
2006	Vincent and colleagues [84]	68	14	HCT < 0.38	40,000 IU/week	Maximum 4 weeks
2006	Silver and colleagues [95]	86	25	< 7 days	40,000 IU/week	Maximum 12 weeks
2007	Corwin and colleagues [88]	1,460	188	Day 3/4	40,000 U/week	Maximum 3 weeks

Number of patients with sepsis is shown and the timing of erythropoietin use. Hb, haemoglobin; HCT, haematocrit; ICU, intensive care unit; ns, not specified.