Table 3.
Circulating blood leukocyte phenotyping in septic shock patients
| Healthy controls | Septic shock patients | ||
|---|---|---|---|
| Days 1 to 2 | Days 3 to 5 | ||
| Leukocytes | 5658 (4,954 to 6,146) | 14,673 (9,562 to 18,446) | 15,390* (10,097 to 25,235) |
| Lymphocytes | 1549 (1,295 to 1,831) | 701* (432 to 1,531) | 1,110 (634 to 1,482) |
| T cells | 1090 (902 to 1,470) | 421* (209 to 547) | 529 (335 to 1,031) |
| CD4+ T lymphocytes | 890 (569 to 1,141) | 220* (115 to 354) | 479 (218 to 827) |
| CD8+ T lymphocytes | 320 (228 to 349) | 155* (36 to 207) | 158 (70 to 304) |
Results expressed as the median (interquartile range, Q1 to Q3) number of cells/μl. Blood samples were obtained from 13 septic shock patients at days 1 to 2 and at days 3 to 5 after diagnosis of shock. Circulating leukocyte immunophenotyping was systematically performed by flow cytometry. The following leukocyte subsets were analyzed: total number of leukocytes, total number of lymphocytes, T cells (CD45+CD3+), and CD4+ (CD45+CD4+CD3+) and CD8+ (CD45+CD8+CD3+) T-lymphocyte subpopulations. Comparison versus healthy volunteers values (mean) performed using the Mann-Whitney U test with correction for the number of tests performed: *P < 0.025.