Table 2.
The predictive value of estimated dead-space fraction at day 1 and day 3 of ALI/ARDS in the Mayo validation cohort, outcome hospital mortality
| Mortality | Odds ratio | 95% CI | |
|---|---|---|---|
| Day 1 | |||
| (Per 0.05 increment of dead space fraction) | |||
| Univariate analysis | |||
| VdVt | 1.33 | 1.09 | 1.69 |
| Multivariate analysis | |||
| Base model (Shock + APACHE III predicted mortality), n= 108 | 1.28 | 1.04 | 1.64 |
| Base model + PaO2/FiO2, n = 108 | 1.26 | 1.08 | 1.61 |
| Base model + OI, n = 107 | 1.25 | 1.02 | 1.61 |
| Base model + PaO2/FiO2 + PEEP, n = 108 | 1.26 | 1.08 | 1.64 |
| Base model + PaO2/FiO2 + PEEP, n = 107 | 1.29 | 1.02 | 1.69 |
| Base model + Vt, n = 108 | 1.32 | 1.05 | 1.70 |
| Day 3 | |||
| (Per 0.05 increment of dead space fraction) | |||
| Univariate analysis | |||
| VdVt | 1.47 | 1.18 | 1.90 |
| Multivariate analysis | |||
| Base Model (Shock + APACHE III predicted mortality), n = 108 | 1.43 | 1.13 | 1.87 |
| Base model + PaO2/FiO2, n = 108 | 1.35 | 1.05 | 1.78 |
| Base model + OI, n = 85 | 1.43 | 1.03 | 2.11 |
| Base model + PaO2/FiO2 + PEEP, n = 108 | 1.35 | 1.05 | 1.79 |
| Base model + PaO2/FiO2 + PEEP, n = 85 | 1.43 | 1.03 | 2.12 |
| Base model + Vt, n = 108 | 1.47 | 1.14 | 1.96 |
ALI, acute lung injury; APACHE, acute physiology and chronic health evaluation; ARDS, acute respiratory distress syndrome; CI, confidence interval; FiO2, fraction of inspired oxygen; PaO2, partial pressureof arterial pressure; PEEP, positive end-expiratory pressure; OI, oxygenation index; VdVt, dead space fraction; Vt, tidal volume.