Table 3.
The predictive value of estimated dead-space fraction at day 1 and day 3 of ALI/ARDS in the ARDS-network validation cohort, outcome hospital mortality
| Mortality | Odds ratio | 95% CI | |
|---|---|---|---|
| Day 1 | |||
| (Per 0.05 increment of dead space fraction) | |||
| Univariate analysis | |||
| VdVt | 1.11 | 1.06 | 1.16 |
| Multivariate analysis | |||
| Base Model (Shock + APACHE III predicted mortality), n = 1616 | 1.09 | 1.04 | 1.14 |
| Base model + PaO2/FiO2, n = 1,610 | 1.07 | 1.03 | 1.13 |
| Base model + OI, n = 1,492 | 1.08 | 1.03 | 1.14 |
| Base model + PaO2/FiO2 + PEEP, n = 1,610 | 1.08 | 1.03 | 1.14 |
| Base model + PaO2/FiO2 + PEEP, n = 1,492 | 1.09 | 1.04 | 1.15 |
| Base model + Vt, n = 1,616 | 1.10 | 1.06 | 1.16 |
| Day 3 | |||
| (Per 0.05 increment of dead space fraction) | |||
| Univariate analysis | |||
| VdVt | 1.18 | 1.12 | 1.24 |
| Multivariate analysis | |||
| Base Model (Shock + APACHE III predicted mortality), n = 1,369 | 1.14 | 1.09 | 1.21 |
| Base model + PaO2/FiO2, n = 1,369 | 1.12 | 1.06 | 1.18 |
| Base model + OI, n = 1,241 | 1.10 | 1.04 | 1.17 |
| Base model + PaO2/FiO2 + PEEP, n = 1,367 | 1.10 | 1.04 | 1.16 |
| Base model + PaO2/FiO2 + PEEP, n = 1,241 | 1.10 | 1.04 | 1.17 |
| Base model + Vt, n = 1,283 | 1.16 | 1.10 | 1.23 |
ALI, acute lung injury; APACHE, acute physiology and chronic health evaluation; ARDS, acute respiratory distress syndrome; CI, confidence interval; FiO2, fraction of inspired oxygen; PaO2, partial pressureof arterial pressure; PEEP, positive end-expiratory pressure; OI, oxygenation index; VdVt, dead space fraction; Vt, tidal volume.