Figure 5.

Activation of coagulation and pulmonary fibrin deposition in antibiotic treated pneumococcal pneumonia. Levels of (a, c) thrombin-antithrombin complexes (TATc) and (b, d) fibrin degradation products (FDP) in (a, b) lung and (c, d) plasma 48 hours after induction of pneumococcal pneumonia in wild-type mice (white white, n = 8) and mice heterozygous (light grey white, n = 8) or homozygous (dark grey white, n = 7) for the factor V Leiden mutation treated intraperitoneally with ceftriaxone 24 hours after infection. Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation. There were no statistical differences between the groups.