Table 1.
Pulmonary MPO, cytokine and chemokine levels 24 and 48 hours after induction of pneumococcal pneumonia
| 24 hours | 48 hours | |||||
|---|---|---|---|---|---|---|
| WT n = 8 |
Heterozygous n = 8 |
Homozygous n = 8 |
WT n = 8 |
Heterozygous n = 8 |
Homozygous n = 8 |
|
| MPO (ng/mL) | 5.2 (3.7-6.7) | 5.0 (4.5-5.6) | 4.6 (3.3-7.5) | 4.6 (2.6-4.2) | 3.7 (2.5-4.2) | 3.4 (2.6-4.2) |
| TNF-α (ng/mL) | 1.2 (0.8-1.8) | 1.4 (0.9-2.1) | 1.5 (0.7-3.0) | 0.8 (0.4-1.3) | 0.9 (0.5-1.5) | 0.8 (0.4-1.9) |
| IL-6 (ng/mL) | 1.5 (1.1-2.8) | 1.9 (0.8-2.2) | 0.5 (0.4-1.9) | 1.5 (0.7-3.0) | 1.5 (0.6-1.8) | 0.3 (0.2-1.8) |
| IL-12 (pg/mL) | 41 (19-53) | 53 (27-102). | 39 (3.1-56) | 36 (18-41) | 43 (23-69) | 18 (3.7-38) |
| IFN-γ (pg/mL) | 107 (57-165) | 69 (56-183) | 50 (35-238) | 84 (39-155) | 58 (47-146) | 42 (24-142) |
| IL-10 (ng/mL) | 1.1 (1.0-1.2) | 0.9 (8.9-1.3) | 0.8 (0.6-1.1) | 1.0 (0.7-1.1) | 0.9 (0.8-1.3) | 0.6 (0.4-0.8) |
| MCP-1 (ng/mL) | 8.4 (2.6-10) | 10 (1.9-14) | 2.8 (1.6-3.0) | 6.3 (2.5-8.9) | 9.0 (1.9-10) | 2.6 (1.3-8.4) |
| KC (ng/mL) | 12 (8.3-15) | 12 (9.6-14) | 9.5 (6.2-15) | 14 (9.1-25) | 8.7 (5.6-14) | 10 (7.2-17) |
| MIP-2 (ng/mL) | 16 (7.5-20) | 21 (11-24) | 10 (5.9-18) | 13 (6.7-23) | 9.6 (3.4-17) | 13 (9.6-18) |
Data are medians (interquartile ranges). No statistical differences between the groups at either time point.
IFN-γ, interferon-γ; KC, keratinocyte-derived chemokine; MCP-1, monocyte chemotactic protein; MIP-2, macrophage inflammatory protein-2; MPO, myeloperoxidase; WT, wild type.