Table 4.

Intravenous treatment of hypophosphatemia

Author [ref.]	Year	Serum phosphate (mmol/L)	Dose	Speed	Efficacy	Complications/safety
Brown et al. [61]	2006	0.73-0.96	0.32 mmol/kg	7.5 mmol/h	No significant increase in iP	Considered safe
		0.51-0.72	0.64 mmol/kg	7.5 mmol/h	iP normalized in 59%	Considered safe
		<0.50	1 mmol/kg	7.5 mmol/h	iP normalized in 60%	Considered safe
Taylor et al. [62]	2004	0.55-0.70	0.2 mmol/kg	33 μmol/kg/h	iP normalized in 76% (all patients)	Considered safe
		0.32-0.55	0.4 mmol/kg	67 μmol/kg/h		Considered safe
		<0.32	0.6 mmol/kg	100 μmol/kg/h		Considered safe
Charron et al. [63]	2003	0.40-0.65	30 mmol	15 mmol/h	Equally effective	Mild hyperphosphatemia and mild hyperkalemia
			30 mmol	7.5 mmol/h
		<0.40	45 mmol	15 mmol/h	Equally effective
			45 mmol	7.5 mmol/h
Perreault et al. [64]	1997	0.40-0.80	15 mmol	5 mmol/h	iP normalized in 81.5%	Considered safe
		<0.40	30 mmol	10 mmol/h	iP normalized in 30%	Considered safe
Rosen et al. [65]	1995	0.50-0.65	15 mmol	7.5 mmol/h	iP normalized in 100%	Considered safe
Bollaert et al. [66]	1995	<0.65	20 mmol	20 mmol/h	iP normalized in 80%	Considered safe Mild hypocalcemia
Kruse et al. [67]	1992	<0.80	20-40 mmol	20 mmol/h	mean iP rose from 0.65 to 1.0 mmol/L	considered safe Mild hypocalcemia

iP, serum inorganic phosphate.