Table 3.
Cardiovascular physiology for the three treatment groups during eight hour study period
| Group | Hour 0 | Hour 2 | Hour 4 | Hour 6 | Hour 8 | |
|---|---|---|---|---|---|---|
|
Heart rate (bpm) |
CVP | 74 (13) | 76 (14) | 76 (14) | 76 (15) | 76 (15) |
| SV | 77 (19) | 76 (17) | 80 (19) | 79 (17) | 78 (17) | |
| § SV & DPX | 77 (11) | 86 (12) | 91 (12) | 93 (13) | 92 (12) | |
| Mean arterial pressure (mmHg) | CVP | 80 (22) | 79 (20) | 79 (15) | 79 (15) | 77 (14) |
| SV | 76 (15) | 81 (15) | 83 (14) | 79 (14) | 77 (14) | |
| † SV & DPX | 80 (18) | 83 (17) | 84 (13) | 77 (13) | 74 (12) | |
| Central venous pressure (mmHg) | ‡ CVP | 6 (5) | 7 (5) | 7 (5) | 8 (5) | 8 (5) |
| * SV | 4 (5) | 6(4) | 6 (5) | 7 (4) | 7 (5) | |
| † SV & DPX | 5 (4) | 7 (4) | 7 (4) | 8 (6) | 8 (5) | |
|
Cardiac index (l/min/m2) |
CVP | 3.5 (1.1) | 3.5 (0.9) | 3.5 (0.9) | 3.5 (0.9) | 3.4 (0.9) |
| ‡ SV | 3.2 (0.9) | 3.5 (0.9) | 3.7 (1.0) | 3.7 (1.0) | 3.6 (1.0) | |
| § SV & DPX | 3.3 (0.8) | 4.0 (0.9) | 4.3 (1.0) | 4.3 (0.9) | 4.4 (1.1) | |
|
Oxygen delivery index (ml/min/m2) |
CVP | 477 (146) | 490 (144) | 480 (152) | 468 (168) | 467 (159) |
| † SV | 449 (145) | 492 (160) | 495 (147) | 499 (165) | 484 (150) | |
| § SV & DPX | 498 (157) | 594 (167) | 635 (198) | 631 (174) | 614 (209) | |
|
Stroke volume (ml) |
CVP | 80 (23) | 86 (25) | 84 (24) | 82 (21) | 81 (21) |
| ‡ SV | 78 (23) | 85 (22) | 84 (22) | 85 (22) | 83 (22) | |
| ‡ SV & DPX | 80 (23) | 88 (24) | 90 (24) | 89 (23) | 88 (26) | |
|
Serum lactate (mmol/l) |
† CVP | 1.4 (1.0-2.1) | 1.1 (0.9-1.6) | 1.1 (0.9-1.8) | 1.2 (0.9-1.8) | 1.2 (0.9-1.8) |
| * SV | 1.4 (0.9-2.7) | 1.3 (0.9-2.2) | 1.3 (0.8-2.4) | 1.2 (0.8-1.9) | 1.2 (0.8-1.8) | |
| SV & DPX | 1.9 (1.3-2.8) | 1.7 (1.0-2.4) | 1.9 (1.0-2.9) | 1.9 (1.0-3.1) | 1.7 (1.1-2.4) | |
|
Base deficit (mmol/l) |
CVP | -1.9 (2.6) | -2.2 (2.7) | -1.7 (2.8) | -1.7 (2.9) | -1.6 (2.6) |
| * SV | -2.2 (2.4) | -2.1 (2.8) | -1.6 (3.1) | -1.0 (2.2) | -1.0 (2.3) | |
| ‡ SV & DPX | -2.2 (2.1) | -2.3 (2.4) | -2.2 (2.4) | -1.9 (2.3) | -1.4 (2.4) |
Data presented as mean (standard deviation) or median (interquartile range). Significant changes over time signified by † (P < 0.05), ‡ (P < 0.01), * (P < 0.001) and § (P < 0.0001). CVP, central venous pressure; DPX, dopexamine; SV, stroke volume.