Table 1.
Comparison of SPRINT and retrospective cohort baseline variables with glycemic control and intervention results
| Overall | |||||
|---|---|---|---|---|---|
| Retrospective | SPRINT | P-value | |||
| Total patients | 413 | 371 | |||
| Age (years) | 64 (53 to 74) | 65 (49 to 74) | 0.53 | ||
| % Male | 59.1% | 63.6% | 0.19 | ||
| APACHE II score | 18 (15 to 23) | 18 (15 to 24) | 0.50 | ||
| APACHE II risk of death | 28.5% (14.2% to 49.7%) | 25.7% (13.1% to 49.4%) | 0.39 | ||
| Diabetic history | 71 (17.2%) | 62 (16.7%) | 0.86 | ||
| LoS median, IQR (days) | 3.8 (1.8 to 8.8) | 4.1 (1.7 to 10.4) | 0.94 | ||
| Median BG (SD) (mmol/L) | 7.2 (2.4) | 6.0 (1.5) | <0.01 | ||
| % BG in 4.4-6.1 mmol/L | 30.0% | 53.9% | <0.01 | ||
| % BG in 4.0-7.0 mmol/L | 49.6% | 80.1% | <0.01 | ||
| % BG < 2.2 mmol/L | 0.2% | 0.1% | <0.01 | ||
| Mean insulin rate (U/hour) | 1.2 | 2.8 | <0.01 | ||
| Mean nutrition (kcal/day) | 1,599 | 1,283 | <0.01 | ||
| APACHE III diagnosis | |||||
| Operative | Num. patients | % | Num. patients | % | P-value |
| Cardiovascular | 99 | 24% | 76 | 20% | 0.24 |
| Respiratory | 10 | 2% | 9 | 2% | 1.00 |
| Gastrointestinal | 53 | 13% | 60 | 16% | 0.18 |
| Neurological | 9 | 2% | 7 | 2% | 0.77 |
| Trauma | 8 | 2% | 14 | 4% | 0.12 |
| Other (Renal, metabolic, orthopaedic) | 4 | 1% | 4 | 1% | 0.88 |
| Non-operative | Num. patients | % | Num. patients | % | P-value |
| Cardiovascular | 41 | 10% | 39 | 11% | 0.79 |
| Respiratory | 77 | 19% | 66 | 18% | 0.76 |
| Gastrointestinal | 7 | 2% | 10 | 3% | 0.34 |
| Neurological | 33 | 8% | 20 | 5% | 0.15 |
| Trauma | 29 | 7% | 32 | 9% | 0.40 |
| Sepsis | 29 | 7% | 17 | 5% | 0.15 |
| Other (Renal, metabolic, orthopaedic) | 14 | 3% | 17 | 5% | 0.39 |
P-values computed using chi-squared and rank-sum tests where appropriate.
APACHE, Acute Physiology and Chronic Health Evaluation; BG, blood glucose (level); IQR, inter-quartile range; LoS, length of stay; SD, standard deviation.