Table 1.
Clinical and laboratory parameters of all patients, survivors, non-survivors before and during treatment with protein C concentrate
| All | Survived (n = 73) |
Died (n = 21) |
P | |
|---|---|---|---|---|
|
Male/female (n) |
52/42 | 42/31 | 10/11 | n.s. |
|
Age (years) |
2.46 | 2.93 | 1.69 | n.s. |
| PC treatment | ||||
|
PC total dose (IU/kg) |
258.8 (127.6-410.9) | 277.8 (132.4-444.4) | 153.8 (126.0-375.0) | n.s. |
|
PC daily dose (IU/kg/d) |
100 (73.4-136.6) | 100 (78.74-133.3) |
81.08 (71.09-153.8) | n.s. |
| PC therapy duration (d) | 2 (1-4) |
3 (2-4) |
2 (1-4) |
n.s. |
|
Bolus/ Bolus + cont. inf. |
78/16 | 61/12 | 17/4 | n.s. |
| Haematological paramenters prior to PC treatment | ||||
|
WBC (pl) |
10.4 (5.0-17.02) |
11.3 (5.3-18.7) |
7.21 (4.6-10.75) |
n.s (0.062) |
|
CRP (mg/dl) |
10.48 (5.65-16.47) |
11.6 (7.81-17.31) |
5.9 (1.99-8.92) |
0.0018 |
|
Platelets (G/l) |
110 (66-183) |
116 (74-182) |
78 (52-178) |
n.s. |
|
PT (%) |
41 (32-54) |
44 (33-56) |
31 (22-36) |
< 0.001 |
|
aPTT (sec.) |
59 (43-91) |
52 (39-71) |
108 (81-160) |
< 0.001 |
|
Fibrinogen (mg/dl) |
270 (174-440) |
347 (217-503) |
129 (82-202) |
< 0.001 |
|
D-Dimers (mg/l) |
2.38 (0.93-8.99) |
2.13 (0.89-8.62) |
6.40 (1.08-12.00) |
n.s. |
|
AT (%) |
76 (57-87) |
80 (60-88) |
70 (46-80) |
n.s. |
|
PC (%) |
27 (14-39) |
30 (18-41) |
10 (10-18) |
< 0.05 |
| Haematological parameters during PC treatment | ||||
|
WBC (pl) |
21.25 (12.75-27.28) |
23.65 (13.65-28.75) |
16.35 (7.7-20.90) |
< 0.05 |
|
CRP (mg/dl) |
14.70 (7.0-21.8) | 15.91 (7.1-23.64) |
9.36 (6.90-15.88) |
n.s. |
|
Platelets (G/l) |
96 (57-130) |
103 (65.5-136.5) |
61 (30-80.75) |
< 0.01 |
|
PT (%) |
69 (48.5-87) |
77.8 (55-91) |
45.5 (37.75-55.75) |
< 0.01 |
|
aPTT (sec.) |
43 (33-52.75) |
41 (33-47) |
61 (47.5-88.4) |
< 0.01 |
|
Fibrinogen (mg/dl) |
558.5 (342-747.2) |
600.5 (418-766) |
214.5 (184-299.2) |
< 0.01 |
|
D-Dimers (mg/l) |
1.95 (0.8-6.16) |
1.6 (0.68-5.96) |
2.93 (1.14-6.4) |
n.s. |
|
AT (%) |
87 (68.5-102.2) |
87 (68-101.5) |
78 (70-102) |
n.s. |
|
PC (%) |
71 (53.5-108.4) |
79 (54.7-106.8) |
68.5 (33.75-108.5) |
n.s. |
Data on patient characteristics, outcome and laboratory findings. Shown as median and inter-quartile range (range between first and third quartile). Note that not all laboratory parameters could be obtained in all patients at each time-point.
aPTT, activated partial thromboplastin time; AT, antithrombin; CRP, C reactive protein; n.s., not significant; PC, protein C; PT, prothrombin time; WBC, white blood cell count.