Table 3.
Relationship between inflammatory marker level 48 weeks after initiation of ART and incident diabetes in HIV-infected persons, with and without additional adjustment for week 48 glucose levels
| Marker | Model excluding week 48 glucose | Model including week 48 glucose |
|---|---|---|
| hs-CRP | ||
| Quartile 1 | Referent | Referent |
| Quartile 2 | 1.09 (0.19–6.36) | 0.65 (0.09–4.69) |
| Quartile 3 | 2.62 (0.51–13.5) | 1.88 (0.28–12.8) |
| Quartile 4 | 4.87 (0.87–27.2) | 2.52 (0.36–17.6) |
| P value, test for trend | 0.05 | 0.18 |
| IL-6 | ||
| Quartile 1 | Referent | Referent |
| Quartile 2 | 1.38 (0.29–6.54) | 1.52 (0.21–10.9) |
| Quartile 3 | 3.94 (0.83–18.6) | 3.34 (0.53–21.1) |
| Quartile 4 | 1.62 (0.31–8.47) | 1.39 (0.23–8.28) |
| P value, test for trend | 0.24 | 0.94 |
| TNFR1 | ||
| Quartile 1 | Referent | Referent |
| Quartile 2 | 5.36 (0.77–37.5) | 2.88 (0.34–24.5) |
| Quartile 3 | 14.0 (1.37–143) | 6.09 (0.61–60.8) |
| Quartile 4 | 39.4 (2.17–716) | 23.2 (1.28–423) |
| P value, test for trend | 0.01 | 0.03 |
| TNFR2 | ||
| Quartile 1 | Referent | Referent |
| Quartile 2 | 2.64 (0.56–12.5) | 1.49 (0.25–8.95) |
| Quartile 3 | 2.38 (0.43–13.1) | 1.01 (0.12–8.31) |
| Quartile 4 | 7.39 (1.18–46.4) | 4.63 (0.60–35.8) |
| P value, test for trend | 0.04 | 0.27 |
Data are odds ratio (95% CI) vs. quartile 1. All models also include age, natural log of baseline marker level, BMI at week 48, CD4 <200 at week 48, and IDV use through week 48.