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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2010 Aug 24;9(9):2536–2544. doi: 10.1158/1535-7163.MCT-10-0332

Figure 2.

Figure 2

Hexon modifications decrease FX-mediated uptake in vitro. Ad vectors were pre-incubated with increasing concentrations of FX and then allowed to infect either A549 (high CAR expression), HepG2 (liver representative, moderate CAR expression), or SKOV3 (low CAR expression) cells. Luciferase transgene expression was measured at 36 hours and normalized for protein and divided over vectors without pre-incubation with FX. Ad5 vectors with wild-type hexon (Ad5) had an increase in transgene expression with increasing FX concentrations. * = p-value of < 0.05 compared to Ad5.