Table 1.

Results from adjusted logistic regression models

Sample or stratum	Cases/controls	OR (95% CI)
		259/259 or 259/X vs. X/X	263/263 or 263/X vs. X/X
Maraganore et al. [6] meta-analysis; all subjects	2,686/2,454	0.85 (0.76–0.96)	1.44 (1.21–1.70)
Kay et al. [5] pooled analysis; all subjects	1,779/2,079	0.83 (0.72–0.95)	1.23 (1.01–1.51)
PEG study [15]; all subjects	333/336	0.93 (0.66–1.29)	1.26 (0.78–2.04)
Caucasians only	290/293	0.93 (0.65–1.31)	1.50 (0.87–2.56)
Family history
Negative	285/247	0.86 (0.60–1.22)	1.43 (0.85–2.39)
Positive	48/33	1.73 (0.64–4.69)	0.48 (0.10–2.25)
Male	184/169	0.81 (0.51–1.27)	1.14 (0.58–2.25)
Female	149/167	1.10 (0.67–1.81)	1.25 (0.61–2.58)
Age of onset
≤68 years	144/168	0.95 (0.57–1.58)	2.26 (1.04–4.91)
>68 years	189/168	0.87 (0.55–1.37)	0.87 (0.46–1.64)
Never smokers	125/100	0.91 (0.50–1.65)	2.81 (1.10–7.16)
Ever smokers	208/236	0.97 (0.65–1.45)	0.88 (0.49–1.58)

X/X represents any other genotype. OR adjusted for age (continuous), sex, education (<12,12 or >12 years), race (White/non-White), smoking status (former, current or never), and family history (positive/negative in a first-degree relative) when not a stratifying variable.