Table 1.
Maternal and fetal characteristics of all treatment groups
| Treatment group | Maternal characteristics |
Fetal characteristies |
||||
|---|---|---|---|---|---|---|
| maternal weight, g | MAP1, mm Hg | litter size, # | resorptions, % | fetal weight, g | placental weight, g | |
| NP control | 302 ± 4.1a,b (n = 12) | 103 ± 1.6a,b (n = 10) | – | – | – | – |
| NP l-NAME | 285 ± 5.0a (n = 11) | 132 ± 4.0c (n = 7) | – | – | – | – |
| NP l-NAME + hydralazine | 273 ± 4.0a (n = 6) | 110 ± 4.9b (n = 5) | – | – | – | – |
| LP control | 378 ± 4.9c (n = 23) | 95 ± 2.0a (n = 12) | 15.0 ± 0.45 (n = 10) | 2/150 (1.3%) (n = 10) | 2.23 ± 0.04b (n = 10) | 0.39 ± 0.04a,b (n = 10) |
| NP l-NAME | 348 ± 5.3b,c (n = 16) | 126 ± 2.0c (n = 16) | 14.0 ± 0.54 (n = 15) | 11/210 (5.2%) (n = 15) | 1.96 ± 0.05a (n = 15) | 0.39 ± 0.01a (n = 15) |
| NP l-NAME + hydralazine | 341 ± 10.5b,c (n = 14) | 103 ± 3.3b (n = 9) | 14.2 ± 0.53 (n = 14) | 9/199 (4.5%) (n = 14) | 2.11 ± 0.10a,b (n = 14) | 0.44 ± 0.01b (n = 14) |
Values are expressed as mean ± SEM, different letters denote statistical significance, p < 0.05.
1
Mean arterial pressure from day 5 of the 10-day treatment (gestational day 14–15 for LP animals).