Table 4.
List of potentially novel burn-responding proteins.
| Gene symbol | Protein name | Burn-T1/Control (Log2Ratio) | Burn-T2/Control (Log2Ratio) | Potential functional implications |
|---|---|---|---|---|
| SIGLEC14 | Sialic acid-binding Ig-like lectin 14 | 1.3 | 0.1 | Immune response 47 |
| CARD11 | caspase recruitment domain family | 0.7 | 1.0 | Immune response45 |
| PPBP | Platelet basic protein | 0.6 | 0.9 | Immune response |
| RNASE1 | Pancreatic ribonuclease | 0.6 | 0.5 | Immune response46 |
| RNASE1 | Pancreatic ribonuclease | 0.6 | 0.5 | Immune response46 |
| GPLD1 | Phosphatidylinositol-glycan-specific phospholipase D | −0.4 | −1.3 | Immune response |
| DBH | Dopamine beta-hydroxylase | −0.9 | −0.2 | Immune response |
| GSN | Gelsolin | −0.8 | −0.8 | Immune response |
| PPIA | Peptidyl-prolyl cis-trans isomerase A | −0.9 | 0.1 | Immune response |
| CHL1 | Neural cell adhesion molecule L1-like protein | 0.3 | −2.4 | Immune response |
| NCAM1 | Neural cell adhesion molecule 1 | −0.6 | −1.3 | Immune response |
| MYO9B | Myosin-IXb | −0.9 | −0.6 | Immune response |
| LRG1 | Leucine-rich alpha-2-glycoprotein | 0.9 | 1.6 | Inflammation, observed in previous LPS study21. |
| CA1 | Carbonic anhydrase 1 | 0.9 | 0.3 | Potential inflammation mediator48 |
| CA2 | Carbonic anhydrase 2 | −1.0 | −1.7 | Inflammation |
| HGFAC | Hepatocyte growth factor activator | −0.1 | −1.3 | Linked with acute phase response49 |
| APOB | Apolipoprotein B-100 | −0.2 | −0.5 | Linked with inflammation50 |
| APOA4 | apolipoprotein A-IV precursor | −0.6 | −0.7 | Linked with inflammation |
| GAPDH | Glyceraldehyde-3-phosphate dehydrogenase | −0.8 | 0.0 | Linked with inflammation |
| CFHR2 | Complement factor H-related protein 2 | −0.3 | 0.7 | Complement system |
| CFH | Complement factor H | −0.9 | −0.4 | Complement system |
| AOC3 | Membrane copper amine oxidase | 0.5 | 1.4 | Cell adhesion56 |
| CDH5 | Cadherin-5 | 0.9 | 1.0 | Cell adhesion57. |
| ANGPTL3 | Angiopoietin-related protein 3 | −1.0 | −1.4 | Cell adhesion |
| KRT10 | Keratin, type I cytoskeletal 10 | 1.4 | 1.1 | Cell movement |
| CAP1 | Adenylyl cyclase-associated protein 1 | 1.2 | 1.4 | Cell movement |
| IGF2 | Insulin-like growth factor II | −0.4 | −1.3 | Metabolic response52 |
| IGFALS | Acid labile chain | −0.8 | −1.7 | Metabolic response52 |
| FBLN1 | Fibulin-1 | 0.9 | 0.1 | Hemostasis and thrombosis58 |
| PGD | 6-phosphogluconate dehydrogenase | 0.9 | 1.6 | Tissue injury marker |
| ALDOA | Fructose-bisphosphate aldolase A | 0.4 | 0.7 | Tissue injury marker |
| LDHAL6A | L-lactate dehydrogenase A-like 6A | 0.8 | 0.9 | Tissue injury marker |
| LCAT | Phosphatidylcholine-sterol acyltransferase | 0.2 | −0.6 | Lipid metabolism59 |
| GPX3 | Glutathione peroxidase 3 | −0.7 | 0.1 | Antioxidant response54 |
| SEPP1 | Selenoprotein P | −1.0 | −0.6 | Antioxidant response53 |
| GLUD1 | Glutamate dehydrogenase 1 | −1.1 | −0.2 | |
| SFN | 14-3-3 protein sigma | 0.4 | 1.0 | |
| BCHE | Cholinesterase | −0.1 | −1.2 | |
| YWHAG | 14-3-3 protein gamma | −0.1 | −0.9 | |
| TAGLN3 | Transgelin-3 | 1.2 | 1.1 | |
| CLEC3B | Tetranectin | −0.7 | −0.7 | |
| FETUB | Fetuin-B precursor | −0.7 | −0.9 | |
| SERPINF2 | SERPINF2 protein | −0.9 | −0.1 | |
| COL18A1 | Collagen alpha-1(XVIII) chain | −0.9 | −0.5 | |
| QSOX1 | Sulfhydryl oxidase 1 | −1.0 | 0.0 | |
| AFM | Afamin | −1.2 | −1.8 |