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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Arthritis Rheum. 2010 Apr;62(4):1051–1059. doi: 10.1002/art.27335

Figure 5. Neutrophils are not essential cellular mediators of arthritis induced by locally administered PGN.

Figure 5

For neutrophil depletion, mice were pretreated with anti-Ly6G neutralizing antibody or isotype control (IC) 18 hours prior to the administration PGN. Mice received an intra-articular injection of 75 μg PGN in one knee and saline was administered to the contralateral knee. Inflammation within the knee joint was assessed 3 days later by NIR fluorescent scanning and histology. A) Representative NIR-fluorescent images of knee joints of isotype control treated (IC) or neutrophil-depleted mice (Anti-Ly6G); B) Quantification of mean NIR-intensity in IC versus anti-Ly6G-treated mice. Data are the mean ± SEM; * p<0.05, comparison between treatments within a genotype; ψ p<0.05 comparison between KO and WT mice treated with PGN (n = 6 mice/treatment/genotype).