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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: Menopause. 2010 Sep–Oct;17(5):978–982. doi: 10.1097/gme.0b013e3181d674d6

Figure 1.

Figure 1

Illustration of the intradermal microdialysis, laser-Doppler probe, and sweat capsule set-up (upper panel). A pump perfuses the drug solution through the microdialysis probe (lower panel). Some of the drug leaves the probe through the 10 mm semipermeable membrane in the middle of the probe. In the present experiment, the drugs L-NAME and ketorolac were infused at sufficient doses to inhibit nitric oxide synthase and prostaglandin synthesis, respectively, while the effects of those drugs on skin blood flow and sweat rate were simultaneous measured during hot flashes. Skin blood flow was indexed via laser-Doppler flowmetry and sweat rate was measured via capacitance hygrometry using compressed nitrogen as the perfusion gas.