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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: J Med Chem. 2008 Sep 25;51(18):5856–5860. doi: 10.1021/jm701517b

Scheme 1.

Scheme 1

Photochemistry of ANQXa

a Upon irradiation with UV light, ANQX (1) forms a highly reactive nitrene (2), which forms two products within the S1S2J binding pocket. The intramolecular reaction results in the formation of FQX (3). The intermolecular reaction results in the formation of a covalent bond with Glu705 in the ligand-binding core (4).