Scheme 1.
Photochemistry of ANQXa
a Upon irradiation with UV light, ANQX (1) forms a highly reactive nitrene (2), which forms two products within the S1S2J binding pocket. The intramolecular reaction results in the formation of FQX (3). The intermolecular reaction results in the formation of a covalent bond with Glu705 in the ligand-binding core (4).