Receiver operating characteristic (ROC) curves for detection of plus disease, in infants at risk for retinopathy of prematurity, using a computer-based image analysis system to analyze arteries (left) and veins (right) during a single session at 35–37 weeks post-menstrual age.*
*For each system parameter (diameter, tortuosity index [TI], integrated curvature [IC]), sensitivity is plotted against (1-specificity) over a range of cutoff values separating “plus” from “not plus.” Diagonal line represents chance performance (area under curve = 0.5).