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. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Am J Ophthalmol. 2010 Oct;150(4):468–475.e2. doi: 10.1016/j.ajo.2010.04.027

Receiver operating characteristic curves for detection of plus disease, in infants at risk for retinopathy of prematurity, using a computer-based system to analyze rate of change in vascular parameters of arteries (left) and veins (below) between a first session at 31–33 weeks post-menstrual age (right) and a second session at 35–37 weeks post-menstrual age. *

^*Rate of change in vascular parameters (diameter, integrated curvature [IC], tortuosity index [TI]) is computed as change per week in the single vessel in each eye found to have undergone highest change for each parameter between sessions. Sensitivity is plotted against (1-specificity) over a range of cutoff values separating “plus” from “not plus.” Diagonal line represents chance performance (area under curve = 0.5).

Receiver operating characteristic curves for detection of plus disease, in infants at risk for retinopathy of prematurity, using a computer-based system to analyze rate of change in vascular parameters of arteries (left) and veins (below) between a first session at 31–33 weeks post-menstrual age (right) and a second session at 35–37 weeks post-menstrual age. *

^*Rate of change in vascular parameters (diameter, integrated curvature [IC], tortuosity index [TI]) is computed as change per week in the single vessel in each eye found to have undergone highest change for each parameter between sessions. Sensitivity is plotted against (1-specificity) over a range of cutoff values separating “plus” from “not plus.” Diagonal line represents chance performance (area under curve = 0.5).