Table 2.

Receiver operating characteristic areas under the curve (AUC) for diagnosis of plus disease using a computer-based image analysis system, using a single session (35–37 weeks post-menstrual age [PMA]) compared to the rate of change between two sessions (31–33 weeks PMA to 35–37 weeks PMA).^*

	Arteries						Veins
	Single session (35–37 weeks PMA)		Highest vessel change/week		Mean vessel change/week		Single session (35–37 weeks PMA)		Highest vessel change/week		Mean vessel change/week
	AUC (95% CI)	p-value	AUC (95% CI)	p-value	AUC (95% CI)	p-value	AUC (95% CI)	p-value	AUC (95% CI)	p-value	AUC (95% CI)	p-value
Diameter	0.760 (0.599–0.922)	N/S*	0.610 (0.416–0.804)	N/S*	0.594 (0.390–0.799)	N/S*	0.789 (0.666–0.911)	0.001	0.712 (0.512–0.912)	0.018	0.617 (0.419–0.815)	N/S*
TI	0.708 (0.599–0.922)	0.039	0.580 (0.395–0.765)	N/S*	0.554 (0.370–0.738)	N/S*	0.734 (0.559–0.909)	0.009	0.819 (0.668–0.970)	<0.001	0.802 (0.646–0.958)	0.001
IC	0.726 (0.564–0.889)	0.024	0.530 (0.345–0.715)	N/S*	0.498 (0.316–0.680)	N/S*	0.952 (0.890–1.013)	<0.001	0.697 (0.489–0.905)	0.029	0.642 (0.412–0.873)	N/S*

^*Wide-angle posterior retinal images were captured bilaterally from 37 infants at two sessions, and computer-based system parameters (diameter, tortuosity index [TI] and integrated curvature [IC]) were calculated from arteries and veins separately. Rate of vascular change between the two sessions was calculated in two ways: (1) change per week in the single vessel in each eye found to have undergone highest change between sessions (“highest vessel change/week”) and (2) as mean change per week in all vessels present in images from both sessions (“mean vessel change/week”).

^*N/S, not statistically-significant.