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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Am J Ophthalmol. 2010 Oct;150(4):534–542.e2. doi: 10.1016/j.ajo.2010.04.031

TABLE 4.

Risk Factors for Loss of Visual Acuity (20/50 or worse) in 92 Eyes with HLA-B27-associated Uveitis

20/50 or worse
Predictors Crude Hazard Ratio (95% CI, P)a Adjusted Hazard Ratio (95% CI, P)b
Duration of uveitis prior to presentation (years) 0.98 (0.92–1.0, 0.43)
Male 1.9 (0.68–5.2, 0.22) 6.0 (2.3–34, 0.001)
Caucasian vs other 2.0 (0.35–11, 0.44)
Chronic disease 2.6 (0.93–7.7, 0.07) 6.8 (3.2–37, <0.0001))
HLA-B27 systemic disease 0.91 (0.33–2.5, 0.87)
Presenting complications
 Posterior Synechiae 6.2 (2.0–18, 0.001) 4.0 (2.5–21, <0.0001)
 Elevated intraocular pressure 2.4 (0.52–11, 0.25)
Oral corticosteroidsc 3.4 (1.2–10, 0.03)
Inflammationc 10 (1.4–2.6, <0.0001) 6.2 (3.3–33, <0.0001)
Corticosteroid-sparing therapyc 2.7 (0.93–7.8, 0.07) 2.6 (1.2–14, 0.021)
Topical corticosteroidsc 3.9 (1.0–15, 0.04)
Corticosteroid injectionsc 6.5 (2.7–35.7, 0.001) 5.1 (5.4–27, <0.0001)
a

Crude HR = hazard ratio (95% CI = 95% confidence interval, P value) for univariate Cox proportional hazard model using robust feature.

b

Adjusted HR = hazard ratio (95% CI = 95% confidence interval, P value) for multivariate analyses in which all exposure variables were included and stepwise regression was utilized to eliminate all variables with P values ≥0.10

c

Time-updated variables