Table 1.

Copper skin penetration as function of skin strata from aq. GHK-Cu solution. Skin permeability coefficients (Kp), steady-state skin penetration flux and lag time for copper tripeptide are shown for isolated stratum corneum, total epidermis and split thickness (dermatomed) human skin, respectively

Exp.	Skin strata	Kp × 104 (cm/h) ± SD	Flux (μg/cm2/h) ± SD	Lag time (h)
A	Isolated stratum corneum (n = 3)	55.9 ± 13.2	38 ± 9	2
B	Isolated epidermis (n = 3)	0.003 ± 0.0006	0.002 ± 0.0004	7
C	Dermatomed skin (n = 8)	2.43 ± 0.51	1.7 ± 0.35	2

Difference in values were considered significant (P < 0.05)