Table 2.
Human skin retention and penetration of copper in function of skin strata
| Exp. | Skin strata | Donor recovered | Stratum corneum | Total epidermis | Dermatomed skin | Receptor fluid | Total % recovered |
|---|---|---|---|---|---|---|---|
| A | Isolated stratum corneum (n = 3) | (79 ± 13) | 290.3 ± 69 | NA | NA | 2110 ± 589 (19.85 ± 3.9) | (98 ± 27) |
| B | Total epidermis (n = 3) | (94 ± 12) | ND | 61.1 ± 13.1 | NA | 0.60 ± 0.21 (0.006 ± 0.001) | (95 ± 12) |
| C | Dermatomed skin (n = 8) | (91 ± 14) | ND | ND | 82 ± 8.1 | 136.2 ± 17.5 (2.0 ± 0.31) | (94 ± 7) |
Amount of copper found in the stratum corneum, total epidermis, dermatomed skin, receptor fluid, donor compartment as well as the total amount recovered are given in μg per cm2 and in percentages of the applied copper dose (in brackets) after 48 h. Difference in values were considered significant (P < 0.05)
NA not applicable; ND not determined