Table 3.

Copper reservoir in skin layers vs. original levels from 0.68% aq. GHK-Cu at 48 h

Skin compartment	Cu at 0 h (μg/cm2)	Cu at 48 h (μg/cm2)	Increase vs. 0 h
Isolated stratum corneum (Exp. A)	0.68 ± 0.3; n = 3	290 ± 69; n = 3	438×
Total epidermis (Exp. B)	0.37 ± 0.2; n = 3	61.1 ± 13.1; n = 3	165×
Dermatomed skin (Exp. C)	1.72 ± 0.5; n = 8	53 ± 8.1; n = 8	31×

Baseline copper levels and copper levels after 48 h exposure to 0.68% copper peptide solution are given for stratum corneum, total epidermis and split thickness (dermatomed) skin. The difference in values were considered significant (P < 0.05)