Table 1.

Treatment recommendations for pancreatic neuroendocrine tumors with von Hippel-Lindau disease[12]

	Treatment recommendation
Prognostic criteria
Tumor size ≥ 3 cm
Mutation in exon 3
Tumor doubling time ≤ 500 d
None of the criteria	Followed by CT/MRI every 2-3 yr
1 criterion	Followed by CT/MRI every 6-12 mo
2 or 3 criteria	Consider surgical intervention

CT: Computed tomography; MRI: Magnetic resonance imaging.