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. 2010 Jul 22;285(40):30741–30751. doi: 10.1074/jbc.M110.105700

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Effects of β1-integrin k/d on TGF-β1 stimulation of type I collagen production in HKC cells. A, COL1A1 mRNA levels evaluated by qPCR. Data are shown from a representative reaction run in triplicates. *, p < 0.01 for effects of knockdown. arb. U, arbitrary units. B, -0.4COL1A2 promoter activity induced by TGF-β1 in the presence of either a β1-integrin expression vector or an empty vector was examined in β1-k/d or control cells. The luciferase activity assayed in triplicates was standardized for β1-galactosidase expression to control for transfection efficiency. A set of representative data (mean ± S.E.) from three independent experiments is shown. *, p < 0.01 for effects of the knockdown, †, p < 0.01 for effects of β1-integrin add-back. arb. U, arbitrary units.