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. 2010 Jul 27;285(40):30804–30813. doi: 10.1074/jbc.M110.166140

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — MH2 domains are responsible for the differential inhibitory effects of I-Smads on signaling from ALK-2. Smad6 and Smad7 were divided into N-terminal (residues 1–330 and 1–259, respectively) and C-terminal (residues 315–496 and 247–427, respectively) moieties (schematically shown left), and inhibitory effects on ALK-2 and ALK-3 signaling were determined by luciferase reporter assay using BRE-Luc in C2C12 cells (right). Expression of each construct was confirmed by immunoblotting. Results are given as percentages of control. Error bars represent S.D.