TABLE 2.
Microarray-based differentially expressed virulence-related genes and their distribution in M1ΔCdhA and M1CdhAΔC55 mutant strains
| M1ΔCdhA |
M1ΔCdhA and M1CdhAΔC55 |
M1CdhAΔC55 |
||||
|---|---|---|---|---|---|---|
| Upa (n = 3) | Downa (n = 9) | Up (n = 2) | Down (n = 5) | Up (n = 3) | Down (n = 6) | |
| NAD-glycohydrolase | SPy0165(×25)b | |||||
| Streptolysin-O precursor | SPy0167(×13.4) | |||||
| Exotoxin C/SpeC | SPy0711(×3.4) | SPy0711 | SPy0711(×3.1) | |||
| DNase/mitogenic factor | SPy0712(×3.2) | SPy0712 | SPy0712(×3.1) | |||
| Streptolysin-S/SagA | SPy0738(×2.3) | SPy0738(×5.7) | ||||
| Cyclomaltodextrin glucanotransferase/AmyA | SPy1302(×6.5) | SPy1302 | SPy1302(×12.3) | |||
| GRAB | SPy1357(×3.6) | |||||
| DNase-mitogenic factor-3/Mf3 | SPy1436(×4.4) | |||||
| Collagen-like surface protein/Scl | SPy1983(×42.2) | SPy1983 | SPy1983(×21.1) | |||
| M-protein/Emm1 | SPy2018(×17.1) | SPy2018 | SPy2018(×7.5) | |||
| Exotoxin-B/SpeB | SPy2039(×12.1) | |||||
| Mitogenic factor | SPy2043(×4.7) | SPy2043 | SPy2043(×3.2) | |||
| Hyaluronate synthetase/HasA | SPy2200(×147) | SPy2200 | SPy2200(×24.5) | |||
a Expression profile (up or down), followed by the number of virulence genes in parentheses.
b Values in parentheses following multiplication symbols denote “x-fold” changes (up or down) in the transcript levels of the corresponding gene.