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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: Nat Immunol. 2009 Feb 1;10(3):314–324. doi: 10.1038/ni.1698

Figure 5. IL-23 promotes effector cytokine profile of TH-17.

Figure 5

(a–d) Intracellular cytokine analysis of wild-type or Il23ra−/− CD45.1+CD4+OTII T cells after transfer into wild-type recipients and immunization with OVA(323–339). (a) Intracellular staining of IL-17 and IL-2 in dLN OTII cells (b) Mean frequency of IL-17+IL-2− cells as proportion of CD4+OTII cells at indicated time points post-immunization. (c) Mean frequency of IL-2+IL-17− cells as proportion of CD4+OTII cells at indicated time points post-immunization. (d) Intracellular staining of IL-17 and IL-2 in blood OTII. Data shown are representative of 4 independent experiments with 4 mice per group.