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. Author manuscript; available in PMC: 2010 Sep 25.
Published in final edited form as: Nat Immunol. 2009 Feb 1;10(3):314–324. doi: 10.1038/ni.1698

Figure 7. Timing of IL-23R requirement during TH-17 differentiation.

Figure 7

(a,b) Anti-IL-23R was administered to recipients of wild-type or Il23ra−/− OTII cells at the indicated times postimmunization. Draining lymph nodes were harvested on day 10 for analysis of intracellular IL-17 and IL-2 (a) and frequency of OTII cells in blood was assessed (b). (c) Clinical score of SJL mice administered anti-IL-23R on days indicated after EAE induction. (d) Delayed type hypersensitivity response in footpads of p19-deficient recipients of wild-type OTII cells ten days postimmunization with OVA(323–339). Where indicated, IL-23 was administered with ovalbumin in the footpad at the time of challenge and mice also received IL-23 in the contralateral footpad. Data shown are each representative of at least two experiments with 5 mice per group.