Table 4.

Studies comparing acetylcysteine administration to control arm in patients undergoing coronary angiography.

Study (N)	CIN definition	Acetylcysteine	Control	P value
Azmus [77] (397)	≥25% or ≥0.5 mg/dL, increase in SCr at 48 hours	7.1	8.4	.62
Boccalandro [81] (179)	≥0.5 mg/dL increase in SCr at 48 hours	13	12	.84
Briguori [82] (183)	≥25% increase in Scr at 48 hours	65	11	.22
Kay [79] (200)	≥25% increase in SCr at 48 hours	4	12	.03
Marenzi [78] (354)	≥25% increase in SCr at 72 hours	15 versus 8a	30	<.001
Webb [80] (487)	>5 mL/min decrease in CrCl	23.3	20.7	.57

CIN, contrast-induced nephropathy; CrCl. Creatinine clearance; IV, intravenous; SCr, serum creatinine, dd, double dose

^aThree arm study: standard dose versus high dose versus placebo.