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. Author manuscript; available in PMC: 2011 Aug 15.
Published in final edited form as: Dev Biol. 2010 May 25;344(2):682–692. doi: 10.1016/j.ydbio.2010.05.499

Fig. 7.

Fig. 7

Effects of MT-DLX3 on Runx2, Wnt10A, TBC1D19, and caspase-3 mRNA expression in odontoblast-like MDPC-23 and preosteoblastic MC3T3E1 cells. Transfection of MT-DLX3 into odontoblast-like MDPC-23 cells significantly decreases TBC1D19 promoter activity (a) and mRNA expression (b) (EV = empty vector; WT = wild type DLX3; MT = mutant DLX3). MT-DLX3 expression significantly reduces Runx2 expression in MDPC-23 cells (c) and significantly increases Runx2 expression in MC3T3E1 cells (d). MT-DLX3 expression significantly reduces Wnt10A expression in MDPC-23 cells (e) but does not significantly changes Wnt10A expression in MCT3T3E1 cells (f). Transfection of siRNA against TBC1D19 increases caspase-3 mRNA expression more than 90-fold (g). Similar results were seen in three independent experiments. Means±SD are presented (*P<0.05, **P<0.005, ***P<0.0005).