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Classification of Candidate Genes on Hyper-IgM/CVID Chip
| Pathways | Number of Genes | Representative Genes |
|---|---|---|
| NF-κB Pathway | 66 | RELA, NFKB1, IKBKG, BCL3, CYLD, MAP2K1 |
| Class-switch, SHM/DNA repair | 33 | CD40, CD40LG, XRCC4, ADA, AICDA, UNG, NBN |
| Immunodeficiency | 13 | ICOS, TNFRSF13B, TNFSF13, MSH4, XBP1, CD79A |
| B-cell development | 9 | PAX5, BLNK, CD70, FOXP1, TNFRSF13C, CD19, TNFSF13B |
| Others | 27 | SIAH1, CRTC2, PELI2, etc |
| Total | 148 | |
