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Expansion ratio of UCAs within blood (GL=0.0 MPa), soft tissue (GL=0.5 MPa) and stiff tissue (GL=1.5 MPa). UCAs with an outer radius of 1 μm and a thickness of 10 nm are insonified by pulses with a PNP of 1.2 MPa and a center frequency of 1.0 MHz: (a) liquid-shelled agent (b) polymer-shelled agent, (c) albumin-shelled agent, and (d) high shear modulus and viscosity agent.
