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. 2010 Sep 24;5(9):e12967. doi: 10.1371/journal.pone.0012967

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Lyons et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Morphology of CPA6 morphants. (B) Schematic illustration of central neural pathways for either lateral or medial rectus mediated optokinetic tracking and saccades. (C) Representative example of eye position (blue trace; top panel), fast phase saccades (green hatching; top panel) and slow phase tracking velocity (cyan trace; bottom panel) in response to ±20°/s velocity steps optokinetic stimuli (grey trace; bottom panel) at 0.0625 Hz. (D) Quantification of saccadic velocity produced by either the lateral (orange bars) or medial rectus muscle (grey bars) in CPA6 morphants and controls. Data are presented as mean ± S.D. (E) Representative eye tracking, saccades and gain in a MO-2 (3 ng) morphant and corresponding control. (F) Optokinetic reflex in MO-3 (6 ng) morphants and corresponding control.