Table 2.
Combined effects of risk variants
| Model | Case/control | OR (95% CI)a | p-valuea |
|---|---|---|---|
| Number of risk allele | |||
| 0–3 | 151/115 | Reference | - |
| 4 | 183/127 | 1.16 (0.83 – 1.63) | 0.3762 |
| 5 | 290/156 | 1.47 (1.08 – 2.02) | 0.0160 |
| 6 | 305/155 | 1.58 (1.15– 2.17) | 0.0044 |
| 7 | 244/121 | 1.60 (1.15 – 2.22) | 0.0057 |
| 8 | 168/74 | 1.82 (1.26 – 2.64) | 0.0015 |
| 9–11 | 118/46 | 1.99 (1.30 – 3.04) | 0.0014 |
| Per allele | 1.11 (1.05 – 1.16) | < 0.0001 | |
| P-value for trend | < 0.0001 | ||
| Percentage of carrying risk allele | |||
| Q1 (≤ 0.417) | 464/319 | Reference | - |
| Q2 (> 0.417 and ≤ 0.5) | 346/176 | 1.35 (1.07 – 1.71) | 0.0114 |
| Q3 (> 0.5 and ≤ 0.6) | 259/133 | 1.36 (1.05 – 1.76) | 0.0190 |
| Q4 (> 0.6 ) | 390/166 | 1.61 (1.28 – 2.04) | < 0.0001 |
| P-value for trend | < 0.0001 | ||
a
Adjusted for age and geographical region using the logistic regression