Figure 2.

Mean±SEM AUC scores on Arousal (a) and Fatigue (b) (POMS) between the three genotype groups at rs2295633 (T/T: n=22; C/T: n=70; C/C: n=67) after placebo and after 10 and 20 mg of amphetamine administration. Amphetamine (10 mg) increased Arousal and decreased Fatigue, relative to placebo, in the rs2295633C/C group as compared with the 2295633C/T and T/T groups. These results are analogous to findings for rs3766246. (^*, significant two-way ANOVA/ANCOVA; ^**, post hoc multiple comparisons between genotypes with Bonferroni correction p<0.05).