Table 3.

Penetration depth of rt-PA and plasminogen measured from the surface of the clot. Measurements were made on dual antibody stained clot sections for each case. The data shown here is mean ± standard deviation for measurements done on sections obtained from three clots for each treatments and 18 measurements of penetration depth made for each section. The peak to peak pressure amplitude for US was 0.32 MPa.

Treatment	rt-PA penetration depth (µm)	Plasminogen penetration depth (µm)
Control	15.2 ±7.5	64.2 ±51.5
rt-PA alone	22.0 ±7.8	65.2 ±36.2
rt-PA, US, PBS infusions without Definity®	52.5 ±21.5	149.9 ±56.9
rt-PA, Definity® infusions and US	221.8 ±54.9	240.9 ±102.8