Table 6.

Changes in progression measures by last visit* and month 24, n/N (%), PP population

Progression measure	Last visit	Month 24
Increase in horizontal or vertical cup/disc ratio by ≥0.2 (visit - baseline)†	98/797 (12.3)	78/676 (11.5)
≥1 postbaseline optic disc hemorrhage‡	29/983 (3.0)	23/785 (2.9)
Decrease in ≥1 rim area, rim volume, and/or mean RNFL thickness by HRT (visit - baseline)†	28/222 (12.6)	13/151 (8.6)
Visual field deterioration rated as progression by physician at ≥1 postbaseline visit‡	137/884 (15.5)	104/630 (16.5)
Increase in Aulhorn stage§ by ≥1 stage (visit - baseline)†	64/370 (17.3)	43/258 (16.7)
Decrease in mean defect by ≥2.5 dB†	59/371 (15.9)	45/285 (15.8)

HRT = Heidelberg Retina Tomograph; PP = per protocol; RNFL = retinal nerve fiber layer.

*Last visit = last postbaseline visit at which the parameter was recorded.

^†To be included in the percentage, a subject must have had assessments at both the baseline and ≥1 postbaseline visit for the relevant measure.

^‡To be included in the percentage, a subject must have had ≥1 postbaseline assessment for the relevant measure.

^§Reflects all methods of determining Aulhorn stage.