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. 2010 Sep 15;10:107. doi: 10.1186/1471-230X-10-107

Figure 3.

Figure 3

Effect of lubiprostone treatment on mucus accumulation in the small intestine as measured by crypt lumen width in WT and CF mice. Crypt widths of Carnoy's fixed, PAS/AB stained sections were used as an estimate of mucus accumulation. A. Frequency distribution of crypt widths in WT control and lubiprostone (+Lubi) treated mice. B. Frequency distribution of crypt widths in CF control and lubiprostone (+Lubi) treated mice. C. Summary of crypt widths in control (Con) and lubiprostone (Lubi) treated WT and CF mice. Horizontal bars represent the group means. (8 WT control, 5 WT + lubiprostone, 6 CF control, 5 CF + lubiprostone; *: P < 0.00001 CF control vs. WT control; + P = 0.00004 CF +Lubi vs. CF control)