Figure 6.

Effect of lubiprostone on small intestinal transit in WT and CF mice. Mice were fasted overnight and in the morning gavaged with the nondigestible, nonabsorbable tracer rhodamine dextran (70 kDa). Twenty minutes later the mice were sacrificed and the distribution of tracer along the small intestine was measured. A. Distribution of rhodamine along the intestine of WT control and lubiprostone (+Lubi) treated mice. B. Distribution of rhodamine along the intestine of CF mice control and lubiprostone treated mice. C. Geometric center of fluorescence in control (Con) WT and CF mice and lubiprostone (Lubi) treated WT and CF mice. Horizontal bars represent the group means. [30 WT control, 12 WT + lubiprostone, 15 CF control, 20 CF + lubiprostone; *: P < 0.00001 CF control vs. WT control; + P = 0.03 WT +Lubi vs. WT control]