Table 2.
Signal | Source | Receptor | Function |
HGF | ECM | c-Met | Activation |
bFGF | ECM/SC | FGFR | Proliferation |
IGF-1 | Circulation/ECM | IGFR-1 | Proliferation |
Myostatin | Circulation/SC | ACVR-2 | Self-renewal |
Wnt | ECM | Frizzled | Cell fate |
BDNF | SC | P75NTR | No differentiation |
Calcitonin | Circulation | CTR | Quiescence |
SDF-1 | Myofiber | CXCR4 | Migration |
EGF | ECM | ErbBR | Activation |
TWEAK | Macrophage | Fn14 | Proliferation |
NO | Myofiber | No receptor | Quiescence |
Delta-1 | SC | Notch | Self-renewal |
VLA4 | Myofiber | VCAM | Fusion |
Laminin | Basal lamina | Integrin | Quiescence |
M-cadherin | Myofiber | M-cadherin | Fusion |
In this table the factors that play a role in muscle SCs quiescence, activation and differentiation are reported, with indicated the source, the receptor that they interact with and their function.