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. Author manuscript; available in PMC: 2010 Sep 27.
Published in final edited form as: J Am Chem Soc. 1994 Sep;116(19):8857–8858. doi: 10.1021/ja00098a075

Figure 1.

Figure 1

Two strategies for the high-affinity binding of single-stranded sequences by triplex formation. Top: Previously reported strategy2a,c,h for binding purine (A,G)-rich sequences. Bottom: Strategy, described herein, for binding pyrimidine (C,T,U)-rich sequences. Not shown are similar T-A-T(U) triad structures for the binding of A (top) or T,U (bottom). Hairpin-like structures can also be used as ligands in both cases if only one loop connects the binding domains (see Table 1).