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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem. 2010 Aug 1;2(10):886–892. doi: 10.1038/nchem.794

Figure 2. A key precursor to cortistatins and its retrosynthetic disconnection.

Figure 2

The azido alcohol intermediate 5 serves as a common intermediate for the synthesis of cortistatin A, J, K, and L as well as cortistatin analogs. This intermediate arises in turn from the cyclohexadienone 6 and the triene 7. The latter intermediate is formed by coupling of the o-vinyl benzylzinc reagent 8 and the enol triflate intermediate 9. TBS = tert-butyldimethylsilyl; TIPS = triisopropylsilyl; Tf = trifluoromethanesulfonyl.