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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem. 2010 Aug 1;2(10):886–892. doi: 10.1038/nchem.794

Figure 3. Preparation of the o-vinyl benzylzinc reagent 8.

Figure 3

The functionalized benzylzinc reagent 8 is prepared from the corresponding Grignard reagent and anhydrous zinc chloride. The Grignard reagent is readily formed from the benzyl bromide 14, which is prepared in multi-gram amounts by a four-step sequence. THF = tetrahydrofuran; Ph = phenyl; DIBAL-H = diisobutylaluminium hydride.