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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem. 2010 Aug 1;2(10):886–892. doi: 10.1038/nchem.794

Figure 5. Synthetic pathways to 17-keto precursors to cortistatins A, J, K, and L from the azido alcohol 5.

Figure 5

a, Synthesis of the 17-keto precursor to cortistatin A (29) by an eight-step sequence. b, A three-step sequence to the 17-keto precursor to cortistatin J (32). c, Synthesis of the 17-keto precursor to cortistatin K (35) by a five-step sequence. d, A four-step sequence to the 17-keto precursor to cortistatin L (38). DMP = Dess-Martin periodinane;18-Cr-6 = 18-crown-6; TFA = trifluoroacetic acid; DMAP = 4-dimethylaminopyridine; Ac = acetyl; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene.