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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Nat Chem. 2010 Aug 1;2(10):886–892. doi: 10.1038/nchem.794

Figure 6. Syntheses of cortistatins A, L, J, and K.

Figure 6

Parallel paths of 17-keto addition of 7-lithioisoquinoline followed by reductive deoxygenation transform each 17-keto cortistatin precursor into the corresponding cortistatin. TMEDA = N, N, N′, N′-tetramethylethylenediamine; TFAA = trifluoroacetic anhydride; AIBN = 2,2′-azobis(2-methylpropionitrile).